When Daxxify hit the scene two years ago, it was touted as the first neuromodulator with a six-month lifespan, almost twice the duration of other wrinkle-smoothers. That promise immediately caught my attention. While I love treatments, going to the treatment room often isn’t my thing. (I’m a once or twice-a-year girl.) But as many early adopters experienced, the first time I had Daxxify treatments when it launched, I didn’t feel like it lasted longer than anything else on the market. Today, Revance, the brand behind Daxxify, has made some tweaks and adjusted the suggested dosage, and it’s gaining traction as an option that really does last. So, I decided to try it again and see if it goes the distance.
The Injection Experience
In May, I was treated by Miami plastic surgeon Jackie Yee, MD. During our consultation, Dr. Yee shared her excitement about the wrinkle relaxer. “When we added Daxxify, we really wanted it—for the longer duration. That’s what I’m so excited about,” she explained. She mentioned that the formula can have a quicker onset for some patients, which was a nice bonus. I didn’t notice that it kicked in faster, but I was more focused on testing out the longevity.
For my treatment, Dr. Yee focused on my forehead and crow’s feet and also treated my neck. I’d never even considered my neck before, but at almost 47, I didn’t hate the idea. In addition to her great skin, I’ve also inherited my mom’s neck lines, which don’t bother me much, but I wanted to see if the treatment made a difference.
June: Effortlessly Smoother Skin
A few weeks after my injections, I traveled to Los Angeles and honestly forgot I’d even had anything done. My skin looked smooth but natural, with no noticeable loss of movement—exactly what I wanted. I totally forgot about my neck lines, which is a testament to the subtle yet effective results. Dr. Yee mentioned that some of her patients notice a glow from Daxxify because it slightly changes the way the skin looks, and I think I saw it, too. It was like a soft filter on my face that brightened everything up.
July & August: Long-Lasting Effects
By July, I started to pay more attention to my skin, wondering when the effects would start to fade. Remarkably, my forehead was still line-free, and even the crow’s feet around my eyes looked softened. “With Daxxify, I find that wrinkles don’t come back as quickly,” Dr. Yee had told me, and I could see what she meant. While previous treatments would begin to wane around the three-month mark, my results seemed nearly untouched.
September: Fading Begins
In September, I finally started to notice subtle changes. The smoothness was beginning to soften, and my expression lines showed up ever so slightly. This is when I understood why Dr. Yee advises patients to be open to varying results: “I tell all my patients, you don’t know if you’re going to be the person who’s going to last nine months… or three months. But you have to try it to know.” For me, it seemed I was heading toward five months, which was already longer than my typical neurotoxin treatments.
October: A Gradual Return
By mid-October, just in time for my 47th birthday, my forehead lines and crow’s feet were back. While I was slightly disappointed not to reach the full six-month promise, I was genuinely impressed that my results held out as long as they did. “Before we had Daxxify, it was every quarter people would come in,” Dr. Yee told me back in May. “Now, for many patients, it’s just twice a year.” Getting nearly five months was a huge plus for someone like me, who is always past due by the time I go back for retreatment.
Final Thoughts
Daxxify may not have reached the full six-month mark for me, but I loved the experience and the gradual, natural fade. It’s clear that Revance’s tweaks to the suggested dosing strategy made a difference in longevity, and for those looking for a longer-lasting alternative, this might be it.
