Best Anti Aging Serum for 50s Skin: Our Top Picks

Naturium Multi-Peptide Advanced Serum ($25)

This new beauty product, with one of the most reasonable price tags on the list, is chock full of peptides. It also features other great ingredients for the skin like encapsulated ferulic acid and collagen. Regular usage results in improved texture and a reduced appearance of fine lines and wrinkles to help you achieve your best skin.

Orveda The Omnipotent Concentrate ($460)

While this is one of the higher prices on the list, this new formula boasts great anti-aging benefits. This product is Orveda’s most potent skin treatment yet, and it’s determined to visibly extend the appearance of youthful skin. The elite formula address past skin damage and present concerns while enhancing skin’s resilience for any future issues, which results in all around anti aging coverage.

Elemis Pro-Collagen Rose Micro Serum ($135)

This lightweight skin plumping serum is clinically proven to deliver 72 hours of hydration while supporting and strengthening the skin barrier. Studies also confirmed that the recently launched product reduces the appearance of fine lines, wrinkles and redness on skin. With collagen as a key ingredient, this serum will help knock years of the age of your skin.

SkinMedica TNS Advanced+ Serum ($295)

Fine lines, deep wrinkles and sagging skin are no match for this powerful potion. The formula works by encouraging skin cell renewal and supporting collagen and elastin levels which results in an all-around more youthful look and texture.

Paula’s Choice Phytoestrogen Elasticity Renewal Serum ($49)

Bring back the youthful bounce in your skin with this elasticity-restoring serum. This dermatologist recommended product is formulated to visibly improve signs of aging in skin like fine lines and crepey skin that coincide with estrogen decline. It’s star ingredients include resveratrol and unique blend of soy-derived equol, genistein and daidzein.

RéVive Intensité Volumizing Serum Ultime Targeted Skin Filler ($600)

Yes, this product is a splurge, but it’s important to note that it’s meant specifically to address the appearance of tiny creases in your skin, not to liberally slather from cheek to cheek. The advanced volumizing technology helps fill in fine lines and wrinkles by plumping, smoothing and restoring volume. It’s perfect for visible furrow lines, nasal labial creases, crow’s feet and other wrinkle-prone areas.

Charlotte’s Magic Serum Crystal Elixir ($80)

This serum boasts both great immediate effects and long-lasting results. A clinical study found that, in eight weeks, skin appears more elastic by 122 percent and firmer by 49 percent. In that same amount of time, the appearance of wrinkles is visibly reduced by 34 percent and pores by 39 percent.

BL+ The Serum ($180)

Not only will this serum target signs of aging it will also optimize skin health over time. The actives ingredients in this formula help hydrate, promote collagen production, prevent UV-induced collagen degradation, combat environmental aggressors and reduce free radical damage, which will contribute to a healthier, younger-looking complexion. Iconic ingredients include vitamin C, blue lagoon seawater and three kinds of hyaluronic acid.

Trinny London Plump Up Peptide+ Hyaluronic Acid Serum ($90)

The advanced peptides in this serum help champion skin’s elastin and collagen production for a plumper complexion with reduced fine lines and wrinkles. The hyaluronic acid quenches parched skin, which helps restore a bit of bounce.

Stripes The Power Move ($85)

This dermatologist approved serum from Naomi Watt’s new line is formulated specifically for (peri)menopausal skin. Five different versions of hyaluronic acid and the star ingredient, ectoine, firm, hydrate and plump skin for a smoother, more radiant complexion.

L’Oréal Age Perfect Cell Renewal Midnight Hydrating Serum ($44)

Say hello to new cells with this dermatologist tested drugstore favorite product. L’Oreal reports that after just one use skin feels refreshed and firmer, and within one week, skin appears brighter and younger. The great ingredient list is packed with antioxidants.

Eve Lom Radiance Repair Retinol Serum ($185)

Gentle yet potent, this is one sophisticated formula. It features wrinkle-fighting liposome encapsulated anti-aging retinol and microbiome re-balancing prebiotic oat kernel ferment to fend off signs of aging without irritation. It results in a firmer, smoother, more even complexion without the usual tricky skin side effects of retinol.

Clinique Smart Clinical Repair Wrinkle Correcting Serum ($99)

This serum is part of Clinique’s most advanced anti-aging line. Scientists and dermatologists helped design the formula, which features ingredients like peptides, retinoids and hyaluronic acid. Clinique studies found the serum to be as effective as one laser treatment on the appearance of fine lines and wrinkles after 16 weeks—need we say more?

Biossance Squalane + Copper Peptide Rapid Plumping Serum ($68)

If lackluster skin is one of the biggest indicators of aging for you, you need this plumping serum with collagen production boosting copper peptides. It immediately hydrates and noticeably improves firmness and elasticity in one week. In four weeks, 100 percent of people said it reduced the appearance of fine lines and wrinkles.

SkinCeuticals CE Ferulic ($169)

This cult-classic dermatologist favorite is great for many things, from brightening skin to protecting against environmental aggressors. However, its most beloved benefits include improving signs of skin aging like fine lines, wrinkles and laxity with it’s potent ingredients like ferulic acid, vitamin C and vitamin E.

True Botanicals Chebula Active Serum ($90)

Among the top-performing anti-aging serums at a fraction of the price, this True Botanicals product is a keeper, and an Olivia Wilde favorite. If you want softer, smoother skin and a reduced appearance of wrinkles in just weeks, grab this bottle. The impressive ingredient list totally transform skin texture.

Clinical Skin PolyPeptide Firming Serum ($250)

This NewBeauty Award winner and dermatologist recommended product employs antioxidants, ceramides, hyaluronic acid and peptides to tackle signs of aging in the appearance of skin. It promises to make skin feel firmer and look smoother, and the results deliver.

Aventura, FL dermatologist Dr. Bertha Baum recommends this product because “it has been shown to reduce fine lines and improve skin texture.”

Maya Chia The Super Lift Vitamin C-More Treatment ($110)

For both a quick fix and long-term skin benefits, Maya Chia’s brightening serum is a great investment. Packed with vitamin C, tranexamic acid, ferulic acid esters, niacinamide, peptides and stem cells, this formula has the ability to brighten skin while also reducing signs of aging. Reviewers claim this the best vitamin C serum they’ve used noting it also smoothed skin texture.

The formula helps firm skin temporarily upon contact, but that’s not all. When using the product, with its unique blend of orange blosson stem cells and pomegranate peptides, overtime collagen production improves up to 157 percent.

Valmont V-Line Lifting Concentrate ($320)

This anti-aging, wrinkle and fine line fighting serum does it all. It protects skin from free radicals, tightens and regenerates tissue and reduces wrinkles in the long-term for an all-around more youthful appearance and skin texture.

OBAGI Medical ELASTIderm Facial Serum ($198)

The unique Bi-Mineral Contour Complex in this formula helps support skin elasticity to help it bounce back from signs of aging more easily. Skin soaks up this fast-acting serum leaving you feeling better just moments after application. Reviewers love it with 100 percent of participants in a clinical study reporting a firmer appearance after 12 weeks of using the product. Reviewers report a notable difference in texture, elasticity and fine lines.

La Prairie Skin Caviar Liquid Lift ($785)

This potent skin firming serum is a luxe favorite with satisfying texture for a sensorial application experience. The formula provides both an immediate lifting sensation and a more lifted appearance over time with continued use. It enhances skin’s firmness, elasticity and volume by helping to restore skin density. You’ll also notice fine lines and wrinkles are visibly reduced after use. Unique ingredients include La Prairie’s Exclusive Cellular Complex and Caviar Premier.

Dieux Skin Deliverance ($69)

A perfect soothing serum for those with aging skin that’s also dry and irritated. Utilizing cannabinoids, niacinamide (vitamin B3) and other calming ingredients, this formula will even out tone, smooth skin, reduce irritation and plump skin. Expect an improvement in skin texture and tone within four to eight weeks of use.

Eminence Firm Skin Acai Booster-Serum ($64)

Superfruit acai is not only a great ingredient for your body, but it’s also great for your skin. Reviewers note fast and noticeable results after using this product, including reduced signs of aging and smoother, more hydrated, plumper, revitalized skin. It features ingreadients rich in vitamin C like wild jujube and maral root alongside acai berry, hyaluronic acid and more.

Epionce Intense Defense Anti-Aging and Repair Serum ($150)

Unique ingredients like Spanish needle, melon fruit extract, shiitake mushroom and flax extract give this great serum an edge. This dermatologist approved formula gets to work on reversing signs of aging while also helping repair the skin barrier. No one will know your age is over 50 after using this product consistently.